Pathogenic microbes are developing resistance to established antibiotics, making the development of novel antimicrobial molecules paramount.One major resource for discovery of antimicrobials is the arsenal of innate immunity molecules that are part of the first line of pathogen defense in many organisms.Gene encoded cationic antimicrobial peptides
Time-dependent neural arbitration between cue associative and episodic fear memories
Abstract Cropped Ribbed Tank After traumatic events, simple cue-threat associative memories strengthen while episodic memories become incoherent.However, how the brain prioritises cue associations over episodic coding of traumatic events remains unclear.Here, we developed an original episodic threat conditioning paradigm in which participants concu
In Vivo Autophagy Up-Regulation of Small Intestine Enterocytes in Chinese Soft-Shelled Turtles during Hibernation
Many studies have focused on how autophagy plays an important role in intestinal homeostasis under pathological conditions.However, its role in the intestine during hibernation remains unclear.In the current study, we characterized in vivo up-regulation of autophagy in enterocytes of the small intestine of Chinese soft-shelled turtles during hibern
Glutathione S-transferase π: a potential role in antitumor therapy
Shu-Chen Dong,1,* Huan-Huan Sha,1,* Xiao-Yue Xu,1 Tian-Mu Hu,2 Rui Lou,1 Huizi Li,1 Jian-Zhong Wu,1 Chen Dan,1 Jifeng Feng1 1Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and Nanjing Medical University Affiliated Cancer Hospital, Nanjing 210009, China; 2Department of Biological Science, Purdue University, West Lafayette, IN, USA